What causes failure of cancer treatments

A team from Stanford University has discovered that the failure of some of the most powerful cancer treatments is due to many cancer cells not being exposed to the drugs because of internal barriers that prevent their access. A study utilizing a new technique to track the movement of the drug within the tumor showed that the medication often concentrates in the outer layers, while the inner part of the tumor remains uninfected, even though the cells inside carry the specific biological target of the therapy. The results also revealed that proteins such as Periostin and FAP contribute to building internal barriers that hinder the spread of drugs within the tumor.

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