Brain changes at 50 may affect dementia risk

New research indicates that around age 50, the brain’s immune cells shift from protective microglia to inflammatory cells originating from the bloodstream, potentially contributing to neuroinflammation and neurodegenerative diseases like dementia. The study analyzed postmortem hippocampal tissue from healthy adults, revealing significant immune cell changes that may influence cognitive decline. Understanding these processes could lead to new strategies for preventing or treating age-related neurological conditions.

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