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A surge in homemade synthetic drugs, including fentanyl and animal tranquilizers like xylazine, is exacerbating the opioid crisis in the US. These potent substances are often cut with other synthetics and distributed in ways that increase overdose risks, with overdoses rising despite widespread naloxone use. Efforts such as drug sampling programs and increased treatment are ongoing, but law enforcement highlights the challenge posed by the adaptability of synthetic drug manufacturing and trafficking.
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