Alzheimer's Involves Bone Marrow

The new study indicates that Alzheimer's disease does not only affect the brain; its impact extends to the bone marrow, where immune cells are formed. Researchers found that the disease disrupts the process of producing a specific type of immune cells, particularly monocytes, which reduces their ability to reach the brain and assist in combating disease-related changes. Experiments on mice showed that restoring the production of these cells led to improved symptoms and a reduction in cognitive decline. The study also revealed that the disease hampers a key warning signal of the immune system, limiting the migration of immune cells to the brain. Additionally, abnormalities in monocyte development were observed in human patients, and it is believed that restoring their production could help alleviate disease-related changes. There is evidence suggesting that the regenerative capacity of bone marrow stem cells diminishes early in affected individuals, accelerating aging within the hematopoietic system.

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