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Two Eli Lilly-funded clinical trials found that experimental drug retatrutide reduced knee pain and improved mobility in adults with obesity and knee osteoarthritis. After 68 or 80 weeks, participants on the highest dose lost about a quarter of their body weight, and roughly two-thirds had at least a 50% reduction in knee pain, compared with 38% on placebo. Retatrutide is not FDA-approved; gastrointestinal problems were common, and serious adverse events occurred more often than with placebo.
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