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A scientific review has shown that treating severe depression during pregnancy with SSRI antidepressants is generally safe, with little to no risk to the mother and baby. The researchers noted that depression during pregnancy, whether antidepressants are used or not, can negatively affect pregnancy health, such as increasing the risk of preterm birth by 46%, decreasing birth weight by 90%, and raising the rates of cesarean sections. Although some studies indicated an increased risk of congenital heart defects linked to medication exposure during the first trimester, deeper analyses revealed that this association often results from the effects of depression itself rather than the medications. The study also found that neonatal adjustment disorder occurs in about 30% of babies born to mothers taking SSRIs, and it is usually temporary. The review emphasized the importance of balancing treatment risks with the benefits of controlling depression to ensure the health of both mother and baby. It also recommends alternative therapies, such as psychotherapy and meditation, and highlights the importance of supporting mental health services during pregnancy.
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