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A mild pain in the foot at night can conceal a serious condition called chronic limb-threatening ischemia (CLTI), a disease characterized by the buildup of plaques in the arteries that leads to worsening blood flow to the legs and feet. This pain is one of the early signs of serious peripheral artery disease complications, which can result in non-healing wounds or ulcers, or even limb amputation in severe cases. Studies indicate that 80% of patients with limb ischemia die within 10 years of diagnosis, highlighting the importance of rapid assessment and treatment, including lifestyle changes, medications, and, in advanced cases, surgical procedures to restore blood flow.
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