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The study clarifies that the human brain is composed of two separate nervous systems from its early developmental stages. The forebrain and midbrain originate from precursor cells carrying the gene "Otx2," while the hindbrain develops from cells containing the gene "Gbx2." This discovery challenges the previous understanding that the brain is a single integrated organ and explains why some processes fail to convert forebrain cells into hindbrain cells. The research, conducted on mouse embryos, opens new possibilities for studying brain functions and developing future treatments using stem cells. It also reveals that the existence of two independent nervous systems is a common feature across ancient organisms such as fish and marine worms.
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