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البلاد
New clue to lower LDL
Researchers at the University of California School of Medicine have discovered a pathway that explains how a cholesterol-rich diet activates the Ral protein and the CTSA enzyme, reducing LDL receptors in the liver and impairing the removal of “bad” cholesterol from the blood. In experiments in mice, inhibiting CTSA stabilized these receptors and lowered LDL. An experimental drug that has passed initial human safety tests may be a candidate for efficacy testing, but its cholesterol-lowering effect in humans has not yet been demonstrated.
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