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A study by researchers at the University of California, published in *Nature Neuroscience*, found an association between the buildup of tau protein in the prefrontal cortex and disrupted slow brain waves during deep sleep—waves that help consolidate memories. Comparing people in their early twenties with participants aged from their mid-sixties to mid-seventies, the researchers found that the older participants’ waves were shorter and more fragmented, and that those with more isolated waves recalled fewer words they had learned the previous night. The findings point to a link between tau, disrupted deep sleep, and impaired memory, but do not prove that tau directly causes memory loss.
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