Study reveals cause of excessive sweating
A recent genetic study has revealed that the true cause of excessive sweating is not a malfunction in the sweat glands, but rather an overactivity of neural signaling resulting from a mutation in the SCN10A gene responsible for the Nav1.8 sodium channel in nerve cells. The study showed that this mutation increases the electrical current flow within nerves, causing them to respond more intensely and stimulating the sweat glands to secrete more sweat. This confirms that the problem originates in the nervous system rather than the glands themselves. This was demonstrated through experiments on genetically modified mice, where disabling the gene or using inhibitors of the Nav1.8 channel restored sweat levels to normal. Additionally, the experiments indicated that known treatments for hyperhidrosis, such as aluminum chloride, glycopyrrolate, and oxybutynin, are effective in mice. Extracts from the cannabis plant (tetrahydrocannabinol and cannabidiol) also significantly reduced sweating, supporting the need for future clinical studies to explore their use as targeted therapies.
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