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Cases of unknown cause chronic kidney disease (CKDu) are raising concerns in Texas, as several hospitals have reported infections among healthy young people, most of whom are workers exposed to high thermal conditions and dehydration, without known risk factors like diabetes or high blood pressure. It is believed that repeated exposure to extreme heat and dehydration leads to recurrent episodes of heat stress and acute kidney injuries, which can accumulate and eventually develop into chronic kidney failure. The disease is often called the "Silent Killer" because it may progress without obvious symptoms and, in its advanced stages, require dialysis or kidney transplantation. Doctors recommend prevention through continuous hydration and avoiding heat stress, along with proper water intake, especially for outdoor workers. The exact cause remains unknown, and uncovering it and identifying the contributing factors represent significant challenges for researchers.
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