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Genetic map links liver to cocaine dependence
American scientists have uncovered new genetic evidence indicating that cocaine addiction mechanisms extend beyond the brain to include the liver as well. They identified that the Ces1 genes, responsible for producing enzymes that break down cocaine, play a key role in determining an individual's susceptibility to addiction. The study showed that changes in cocaine metabolism through the liver influence drug-taking behavior, supporting the idea that addiction is a comprehensive disorder involving multiple body systems, not just the brain. The researchers suggest that modifying the activity of Ces1 genes could lead to treatments aimed at reducing the risk of addiction by targeting the entire body.
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