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A recent study has revealed that supercentenarians—individuals over the age of one hundred—exhibit a significant increase in tumor-fighting T cells known as CD4 cytotoxic T lymphocytes (CD4 CTLs). Their levels rise with age, reaching 17.6% in those over 100 years old, compared to just 4% in people aged 70 to 99. The findings suggest that this increase reflects an early immune response to hidden threats, although it has not been proven that these cells directly prevent cancer or extend lifespan. The study opens new horizons for understanding the role of the immune system in achieving exceptional longevity and cancer prevention, while emphasizing the need for future research to explore the behavior of these cells within tissues.
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