Study warns of risks from common fertility drug
The study published in BMJ Open explores the impact of high cumulative doses of clomiphene citrate on pregnancy. It found that doses between 500-749 mg are associated with a 12% increased risk of miscarriage, which rises to 38% at doses of 750-999 mg. Additionally, higher doses increase the risk of twins and multiple births, although there is no statistically confirmed increase in fetal mortality at the highest doses. The medication has been in use since 1967 and is one of the common treatments for ovulation induction. Therefore, researchers recommend avoiding unnecessary doses and balancing the benefits with safety.
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