Natural mechanism identified for chronic disease treatment
Researchers from University College London have identified a natural mechanism that helps the body resolve inflammation more quickly. This process reduces damage caused by persistent inflammation to healthy tissues and limits the development of chronic diseases such as arthritis, heart disease, and diabetes. The study, published in Nature Communications, showed that small lipid molecules called epoxy-octadecenoids act as brakes on the immune system by decreasing the accumulation of monocytes associated with chronic inflammation. In experiments involving healthy volunteers, inhibiting the enzyme sEH with the drug GSK2256294 led to an increase in these molecules, which contributed to speeding up pain reduction and decreasing the number of these cells in blood and tissues, without significant changes in redness or swelling. This discovery paves the way for new clinical trials targeting chronic inflammatory diseases.
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