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وكالة صدى نيوز
Science reveals secrets of human aging
Recent studies explore new models of aging biology, emphasizing that the aging process is not limited to wear and tear alone but also involves the loss of cellular identity. The research indicates that the deterioration of the epigenetic architecture, particularly through the decline of the PRC2 complex, leads to the breakdown of epigenetic boundaries and the loss of cell identity. This results in mid-life abnormalities such as the formation of inflammatory scars and collagen deposits. These phenomena contribute to the development of age-related diseases, including atherosclerosis and Alzheimer's disease. Interventions such as calorie restriction or partial cell reprogramming may help preserve or restore cellular identity, potentially extending human lifespan and reducing aging-related effects. Additionally, studies have shown that lithium may help maintain neuronal cell identity, opening new avenues for treating age-related disorders.
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