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A U.S. trial involving 18 people aged 65 and older found that consuming 48 grams a day of freeze-dried blueberry powder—equivalent to about two cups of fresh blueberries—for three months was associated with a greater improvement in depressive symptoms than placebo powder, though the difference was not statistically significant. Researchers also observed changes in the genes of some gut bacteria, but did not establish that these changes caused the improvement in mood. Given the study’s small size and limited number of participants, the findings do not prove that blueberries are effective or make them a substitute for psychotherapy or medication.
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