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وكالة الأنباء القطرية
Genetic tweaks boost immune cell tumor infiltration
A recent study has revealed that genetic modifications to immune cells, particularly disrupting the GNAS and P2RY8 genes, enhance their ability to penetrate and more effectively attack solid tumors. Experiments on mice showed that disabling P2RY8 increases the accumulation of immune cells within tumors, while knocking out GNAS boosts interferon-gamma production and reduces the suppression of T-cell responses, thereby supporting the effectiveness of immunotherapy. Although these modifications have shown success in treating blood cancers such as leukemia, their effectiveness against solid tumors like lung, pancreatic, ovarian, and breast cancers remains limited. There is also potential to develop more specialized immunotherapies using CRISPR technology to explore additional genetic modifications.
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