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Unraveling Intestinal Inflammation
A recent study published in The New England Journal of Medicine has uncovered a biological mechanism that had remained a mystery for over 30 years in inflammatory bowel diseases such as Crohn's disease and ulcerative colitis. The findings revealed that the presence of antibodies that disrupt the effect of interleukin-10, a molecule that regulates the immune response and reduces inflammation, is associated with the genetic variant HLA-DRB1*01:03. This explains its connection to the severe forms of the disease and may contribute to the development of more precise and targeted treatments.
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