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New mitochondrial protein linked to diabetes
A study from the University of Southern California has revealed a new hidden protein within the mitochondrial genome called MENTSH, which may help explain some causes of Type 2 diabetes. Research shows that this protein enhances the body's cells' response to insulin and operates differently depending on the tissue type; it supports insulin pathways in muscles and suppresses them in fat tissues, thereby improving metabolic health. Additionally, the presence of a genetic variant linked to the protein was associated with an increased likelihood of developing the disease. Experiments also succeeded in reducing weight gain in mice fed a high-fat diet. This discovery represents an important step toward understanding the causes of diabetes and obesity and could pave the way for more precise and effective treatments in the future.
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