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Effects of stress on arthritis
A study from Chiba University in Japan confirmed that stress reactivates rheumatoid arthritis through a biological pathway that begins with the activation of the autonomic nervous system. This activation stimulates brown fat to release interleukin-6 protein, which attracts neutrophil cells and perpetuates inflammation in the joints. The findings suggest that stress can reinforce the "inflammatory memory" in tissues, causing some cells to respond again despite symptom improvement. However, the study did not establish the same pathway occurring in humans. These results help explain why stress often coincides with the return of pain and swelling after a period of remission, even with treatment. They also highlight the importance of managing psychological stress to control chronic inflammatory conditions.
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