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Sharjah24
Genetic factors linked to sudden cardiac death
A recent study conducted by the University of Birmingham, in collaboration with Oxford and the Harwell Research Campus, reveals that genetic alterations in the protein "Alpha-Actinin-2" (ACTN2) directly contribute to hypertrophic cardiomyopathy, one of the causes of sudden cardiac death in healthy, highly fit individuals. These changes weaken the stability of the protein and increase its aggregation, especially in the "actin-binding domain," significantly impacting the heart muscle's function. The findings aid in understanding the genetic mechanisms of the disease and suggest the potential for developing more precise diagnostics and treatments targeting its genetic basis.
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