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Japanese researchers have discovered that pigment cells in vitiligo do not completely disappear; instead, they regress to an immature pattern and lose their ability to produce pigment due to changes in cell membrane proteins. The study showed that alterations in the concentration of the membrane protein LAMININ-332 in the skin of vitiligo patients lead to the decline of pigment cells. These cellular pathways can be targeted to reactivate the cells, restore their function, and re-pigment the skin. This discovery opens new horizons for treatments that focus on reactivating pigment cells rather than solely suppressing the immune response. It represents an important step toward improved therapy for the disease.
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