Obesity-Linked Memory Impairs Fat Loss
A study from the University of Tokyo has found that immune cells in adipose tissue retain a "memory of obesity," which hinders continued weight loss after it begins. Experiments showed that ongoing changes in macrophage cells contribute to the difficulty in eliminating fat, with a decrease in the CCL22 protein and the persistent influence of more than half of the genes associated with obesity remaining after weight loss. This explains the difficulty patients with obesity face in maintaining weight loss results.
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