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A comprehensive study involving more than 3.3 million people found that a rare genetic mutation in the epidermal growth factor receptor (EGFR T790M) significantly increases the risk of lung cancer, especially among non-smokers, with an increase of up to 60 times compared to those without it. Among smokers, the risk is about ten times higher. The results suggest that genetic testing could be relied upon to identify individuals at higher risk of developing the disease and to improve future screening processes. Although traditional screening currently depends on smoking history, this mutation was associated with an increased risk of lung cancer. This study is the first to assess the connection between this mutation and cancer risk through analysis of data from millions of individuals, highlighting the importance of genetic testing for early detection.
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