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The study focused on identifying blood biomarkers that can predict memory decline and cognitive abilities before the appearance of Alzheimer's disease symptoms by several years. The results showed that elevated levels of the protein p-tau181 are associated with cognitive deterioration after six years, despite no correlation at the beginning of the study, making it an early indicator of future cognitive changes. Additionally, the researchers examined other markers such as Aβ42/40, GFAP, and NfL, which may help provide a comprehensive picture of changes related to cognitive decline. Combining these indicators could facilitate early identification of at-risk individuals, enhancing the prospects for early intervention to protect mental abilities.
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