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Consuming coffee interacts with the absorption and effects of many medications, which may lead to increased or decreased efficacy or the appearance of side effects. Among the drugs that require caution when taken with coffee are cold and flu medications containing pseudoephedrine, as combining them can increase tension and symptoms associated with high blood pressure, especially in diabetic patients. Drinking coffee also affects the absorption of thyroid medications like levothyroxine, where taking it immediately after the medication reduces its effectiveness, potentially causing symptoms of hypothyroidism to reappear. Caffeine also impacts certain antidepressants and antipsychotics by raising their levels in the blood and increasing the risk of side effects such as drowsiness and confusion. To minimize these interactions, it is advisable to time medication intake appropriately—for example, waiting at least an hour after taking sensitive drugs or blood pressure medications—and to inform your doctor about your coffee consumption habits.
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