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A recent archaeological and medical study has revealed that surgeons from the Ming Dynasty era in China (1368-1644) devised a anesthetic mixture based on the toxic plant "Wolfbane" (Aconitum). This plant contains aconitine, a substance that depresses nerve activity and relieves pain. Traces of this compound have been found on surgical tools from that period, indicating that ancient physicians managed to control dosages and reduce toxicity through methods such as boiling or soaking, enabling them to effectively manage pain despite the plant’s dangerous nature. Modern research now aims to extract the active components of this traditional anesthetic for analytical purposes and to improve pain management techniques.
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