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A scientific review indicates that abnormally high or low levels of testosterone increase men's risk of developing atrial fibrillation, an irregular heart rhythm that raises the likelihood of stroke. The findings show that the risk of arrhythmia is higher at both ends of the testosterone spectrum, with the lowest risk around the mid-normal range (350-550 ng/dL). Researchers recommend careful monitoring of testosterone levels and avoiding sharp increases by using stable formulations, along with addressing risk factors such as obesity and hypertension before starting testosterone replacement therapy.
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