Seasonal Changes Impact Human Genes

A comprehensive international study reveals that approximately 85% of human genes exhibit fluctuations in their activity within an individual over time, surpassing the differences observed between different people. The study showed that seasonal changes—such as increased immune gene activity during winter—lead to significant biological variations that can result in two entirely different patterns within the same person during summer and winter. Furthermore, about 15% of genes—particularly those linked to the immune system—remain stable and constitute each person's unique "immune fingerprint." The findings also indicated that women experience higher levels of genetic fluctuations over time compared to men, even after menopause. This raises questions about deeper factors that are not yet understood, prompting a reevaluation of clinical study results, as some natural biological changes may be associated with time, season, or gender. The researchers suggest it is necessary to update research methodologies to include repeated measurements that consider timing and surrounding biological factors.

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