Sleep clues to depression

A study of 11,380 Australian adults with a history of depression found that about 23% met criteria for a proposed “circadian depression” profile, marked by sleep-wake patterns such as being an evening person, waking tired or having major shifts in sleep timing. Those in the group reported earlier-onset, more severe depression and poorer responses to two common classes of antidepressants. Researchers said the profile is not a formal diagnosis, and the study could not determine whether disrupted body-clock rhythms cause depression or result from it.

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