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A study by researchers at McGill University has found that some immune T cells can sense the stiffness of tissues and adapt to it, rather than responding only to chemical signals. Experiments with human and mouse cells in collagen gels of varying stiffness showed that stiffer environments make the cells more likely to acquire the characteristics of tissue-resident memory cells, which provide long-term protection. The researchers believe the findings could help advance treatments for autoimmune diseases, allergies, organ rejection and cancer, and are working to identify the molecular sensor responsible.
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