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الصحة والعلوم الشرق الأوسط
Can joint stiffness be prevented
Researchers from the University of Utah in the United States have developed a new pharmaceutical compound targeting the root cause of osteoarthritis using artificial intelligence and genetics techniques. The study focused on inhibiting the gene "WNK2," which contributes to activating inflammatory pathways that lead to cartilage deterioration. Through computational simulations, over 500,000 chemical compounds were evaluated, resulting in the identification of six promising candidates. One of these, labeled "M04," demonstrated notable effectiveness in reducing inflammatory changes and promoting genes that maintain cartilage health in laboratory experiments. The researchers are currently exploring the possibility of developing it as a treatment that targets the fundamental mechanisms of the disease, aiming to slow its progression and reduce the need for surgeries, potentially adding years of pain-free life for patients.
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