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A review of medical records for more than 256,000 adults with obesity and prediabetes over three years found that GLP-1 medications were associated, compared with metformin, with a 50% higher likelihood of blood sugar returning to normal levels, a 31% lower risk of type 2 diabetes, and a 41% lower risk of death from any cause. Their use was also associated with fewer heart attacks (15%), strokes (20%), cases of heart failure (25%), and cases of atrial fibrillation (8%). A researcher suggested that some of these benefits may be related to weight loss, while metformin remains the first-line treatment because of its safety and low cost.
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