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A new study reveals that the paintings of Italian artist Sandro Botticelli, including "The Birth of Venus," show potential signs indicating the death of the famous muse, Simonetta Vespucci, due to a pituitary tumor. Analyses suggest that changes in her facial features and eyes may reflect symptoms such as headaches, vomiting, hallucinations, and issues with eye movement, which could have resulted from bleeding or a clot in the pituitary gland. These findings support the hypothesis that she died at a young age of 23 in 1476. However, due to the passage of centuries, it is impossible to definitively determine the exact cause of her death, although the paintings provide important medical clues.
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