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A new study has shown that long-term use of melatonin supplements, especially for a year or more, is associated with an increased risk of heart failure and death from any cause among individuals with chronic insomnia. The researchers recorded a 90% rise in heart failure rates and a three-and-a-half times higher rate of hospitalizations over five years among long-term users, with mortality nearly doubling compared to the group not using melatonin. Although the study does not establish that melatonin is the direct cause, it raises concerns about its safety, particularly since it is often considered a “natural” and safe supplement and is frequently used without a prescription.
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