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Turmeric or curcumin supplements, especially at high doses or when taken with substances that enhance absorption, may cause liver damage. The Drug-Induced Liver Injury Network linked these supplements to 10 of 2,392 suspected cases, after an average of 86 days of use. Signs of liver injury include jaundice, abdominal pain, nausea, dark urine, fatigue, and loss of appetite. Seek medical advice if these symptoms occur. Typical amounts of turmeric in food are generally safe. For supplements, follow the recommended dosage and consult a doctor before taking them; in general, it is not advisable to exceed 8 grams of curcumin per day. People with liver disease, those who are pregnant or breastfeeding, and anyone taking medicines that may affect the liver or interact with turmeric should avoid these supplements or consult a doctor about using them.
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