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Why Cholesterol Drugs Fail
A study published in *Nature* found that a cholesterol-rich diet may activate Ral GTPase proteins and the enzyme CTSA, causing LDL receptors in the liver to be destroyed rather than recycled and reducing the removal of harmful cholesterol from the blood. In laboratory experiments, inhibiting CTSA helped protect the receptors and improve their stability, potentially opening the way to treatments that target a pathway independent of PCSK9. However, the findings are still at the laboratory research stage and do not mean that a new treatment is currently available.
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