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الوطن
Molecular basis of heparin clots
A research team at the University of Manitoba has gained new insight into the mechanism behind the dangerous blood clots often seen in patients receiving heparin. They discovered that changes in the shape of the protein "Platelet Factor 4" (PF4) after heparin use trigger a harmful immune response, leading to clot formation that can be life-threatening, such as strokes or heart attacks. Using magnetic resonance spectroscopy, the researchers identified that maintaining the protein's conformation in its closed form reduces the likelihood of provoking this response. This finding could help develop more precise diagnostic and treatment options for this immune condition known as "Heparin-Induced Thrombocytopenia."
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