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An international team of researchers from Kyoto University in Japan and the Egan School of Medicine in the United States has discovered a new biological therapeutic approach to combat lung infections and asthma attacks, based on stimulating the external ear nerve. The study, published in the journal "Immunity," demonstrated that stimulating the auricular branch of the vagus nerve significantly reduces lung inflammation by increasing levels of the signaling molecule "CGRPβ," while inhibiting this pathway led to increased severity of the disease. This neural mechanism linking the skin of the ear to the lungs is a novel discovery that could pave the way for developing bioelectronic treatments for inflammatory diseases. Such treatments could offer an alternative to traditional pharmacological methods, with potential applications in treating pulmonary fibrosis, inflammatory bowel disease, and rheumatoid arthritis.
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