Creatine and mood effects

A research review of five trials involving 238 patients found that two trials suggested creatine may help relieve depression, while the other three reported no positive results. Studies indicate that people with depression may have lower creatine levels in a brain region involved in mood regulation, but the current evidence is limited and does not conclusively establish its effectiveness. The appropriate dose and duration are still unknown, so researchers currently recommend getting creatine through a balanced diet.

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