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3 better antidepressants
An analysis of 21 antidepressants across 115 studies found that escitalopram, duloxetine, and agomelatine were associated with a greater likelihood of improvement in depressive symptoms—and of sustaining that improvement—than fluoxetine (Prozac). The studies included patients with major depressive disorder and followed them for more than 12 weeks. Bupropion and reboxetine, meanwhile, performed less well than other antidepressants. The researchers emphasized that medication choice depends on the patient’s symptoms and medical history, as well as the treatment’s effectiveness and how well the patient tolerates it.
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